• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

Elacestrant dihydrochloride

CAS No. 1349723-93-8

Elacestrant dihydrochloride ( RAD-1901 dihydrochloride )

产品货号. M11413 CAS No. 1349723-93-8

Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD).

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥2017 有现货
10MG ¥3208 有现货
25MG ¥5387 有现货
50MG ¥7671 有现货
100MG ¥10368 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Elacestrant dihydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD).
  • 产品描述
    Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD); inhibits ERα expression in MCF-7 cells (IC50=0.6 nM); induces the degradation of ER, inhibits ER-mediated signaling and growth of ER+ breast cancer cell lines in vitro and in vivo, and significantly inhibits tumor growth of multiple PDX models.Breast Cancer Phase 2 Clinical
  • 同义词
    RAD-1901 dihydrochloride
  • 通路
    Endocrinology/Hormones
  • 靶点
    Estrogen Receptor/ERR
  • 受体
    Estrogen Receptor/ERR
  • 研究领域
    Cancer
  • 适应症
    Breast Cancer

化学信息

  • CAS Number
    1349723-93-8
  • 分子量
    531.56
  • 分子式
    C30H40Cl2N2O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 17.6 mg/mL
  • SMILES
    ——
  • 化学全称
    2-Naphthalenol, 6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-, hydrochloride (1:2), (6R)-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Wardell SE, et al. Endocr Relat Cancer. 2015 Oct;22(5):713-24.
2. Garner F, et al. Anticancer Drugs. 2015 Oct;26(9):948-56.
3. Bihani T, et al. Clin Cancer Res. 2017 May 4. pii: clincanres.2561.2016.
产品手册
关联产品
  • Estriol

    Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast Y cells.

  • Norgestrel

    Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception.

  • OP-1074

    OP-1074 (OP1074) is a potent, selective ER degrader (SERD), shows specific antiestrogenic activity for both ERα and Erβ.